zum Inhalt springen

New Paper published in Journal of Nanostructure in Chemistry

Asymmetric attachment and functionalization of plasmonic nanoparticles on ceramic interfaces

Daniel Stadler, Shifaa Mohammed Siribbal, Isabel Gessner, Senol Öz, Shaista Ilyas, Sanjay Mathur

Abstract

The demands for materials that integrate more than one functional imaging or therapeutic unit are of increasing interest for biomedical applications. Here, we present the step-by-step preparation of asymmetric and optically active particles, namely, Gd2O3@Ag, Gd2O3@Au, SiO2-N3@Au, and SiO2-SH@Au . Successful attachment of plasmonic nanoparticles to the surface of metal-oxide spheres without necessity of a potentially toxic inter-adhesive layer was proven by optical methods as well as X-ray photoelectron spectroscopy. The combination of optical and magnetic properties as present in Gd2O3@Ag and Gd2O3@Au Janus-type particles leads to dual-imaging probes for optical and magnetic resonance imaging. In addition, functional groups, such as azide groups, were linked to the surface of silica particles previous to Au nanoparticle attachment. Subsequent site-selective click reactions with 5-FAM were successfully performed as demonstrated by UV-Vis measurements. All described systems exhibited excellent long-term stability and can, therefore, be considered as promising candidates for theranostic applications.

J. Nanostructure Chem. 2018.

Öffnet externen Link in neuem FensterDOI 10.1007/s40097-018-0252-y.  

© 2017 Springer International Publishing AG